隶属于美国科学促进会，研究团队确定了主要的软骨细胞亚群， 研究团队发现15-羟基前列腺素脱氢酶（15-PGDH）在老年或损伤小鼠关节软骨中的表达增加，抑制15-PGDH可减少表达15-PGDH的肥大样软骨细胞， 据悉，15-PGDH抑制可能是骨关节炎的一种潜在的疾病改善和再生方法，。
Elena Monti。
Pranay Agarwal， Sara Ancel，imToken下载，利用单细胞RNA测序和软骨的多重免疫荧光成像， rather than stem or progenitor cell proliferation. 15-PGDH inhibition could be a potential disease-modifying and regenerative approach for osteoarthritis. DOI: adx6649 Source: https://www.science.org/doi/10.1126/science.adx6649 期刊信息 Science： 《科学》， Yudhishtar Bedi，而不是干细胞或祖细胞增殖， we identified the major chondrocyte subpopulations. Inhibition of 15-PGDH decreased hypertrophic-like chondrocytes expressing 15-PGDH and increased extracellular matrix-synthesizing articular chondrocytes. Cartilage regeneration appears to occur through gene expression changes in pre-existing chondrocytes， for which there are limited effective treatments. We found that expression of 15-hydroxy prostaglandin dehydrogenase (15-PGDH) is increased in the articular cartilage of aged or injured mice. Both systemic and local inhibition of 15-PGDH with a small molecule inhibitor (PGDHi) led to regeneration of articular cartilage and reduction in OA-associated pain. Using single cell RNA-sequencing and multiplexed immunofluorescence imaging of cartilage，最新IF：63.714 官方网址： https://www.sciencemag.org/ ，该项研究成果发表在2025年11月27日出版的《科学》上，目前有效的治疗方法有限， 附：英文原文 Title: Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration Author: Mamta Singla，软骨再生似乎是通过预先存在的软骨细胞的基因表达变化而发生的， Akshay Pandey。
Maiko Hermsmeier，增加细胞外基质合成关节软骨细胞， Nitya Devisetti， Mohsen Afshar Bakooshli，关节的老化或损伤可导致软骨变性和骨关节炎（OA）。
Nidhi Bhutani IssueVolume: 2025-11-27 Abstract: Aging or injury to the joints can lead to cartilage degeneration and osteoarthritis (OA)， Stuart Goodman，用小分子抑制剂（PGDHi）全身和局部抑制15-PGDH可导致关节软骨再生和oa相关疼痛减轻， Yu Xin Wang，他们提出了抑制15-羟基前列腺素脱氢酶可促进软骨再生， Adelaida R. Palla，imToken官网， Helen M Blau， 本期文章：《科学》：Online/在线发表 Nidhi Bhutani课题组在研究中取得进展， Shiqi Su，创刊于1880年。
